• PGC mediated mitochondrial biogenesis in

  2024-10-14

  

  PGC-1α-mediated mitochondrial biogenesis in brown fat and endothelial HU 308 is in part regulated by eNOS and NO [28], [29]. Recent studies indicate that H2S not only augments NO bioavailability and signaling [11], [17], but provides protection against cardiac injury in an eNOS-dependent manner [15

• br Acknowledgements This work was supported by Programme

  2024-10-14

  

  Acknowledgements This work was supported by Programme Grants from the MRC and the Wellcome Trust (SGC-C and MF). CB was in receipt of a Marie Curie Intra-European Fellowship during part of this work. We thank past and present members of our group for numerous valuable discussions throughout these

• Neural activity resulting from sensory experience

  2024-10-14

  

  Neural activity resulting from sensory experience is required for the refinement and maturation of neural circuits during cortical critical periods. This refinement is thought to be important for functional optimization of primary sensory cortices, enabling critical functions such as feature detecti

• To date defining the prognostic impact of molecular drivers

  2024-10-14

  

  To date, defining the prognostic impact of molecular drivers of early-stage NSCLC has been challenging due to the relative rarity of these subsets and the redefinition of comparator arms over time as understanding of the molecular drivers of NSCLC evolved. Indeed, use of molecularly heterogeneous co

• Extracellular adenosine acts as a local

  2024-10-12

  

  Extracellular adenosine acts as a local modulator of cell function via four adenosine receptor subtypes (A1Rs A2AR, A2BR, and A3R) that are involved in numerous physiological and pathophysiological processes [31]. Each is encoded by a separate gene and has different functions, although with some ove

• The AR signalling pathways play important roles

  2024-10-12

  

  The AR signalling pathways play important roles in several physiopathological processes associated with ischaemia, inflammation, and tumourigenesis [35]. Moreover, A3AR is overexpressed in different tumour pi3k inhibitor and seems implicated in pro- or anti-apoptotic effects [36]. In particular, ac

• br Conclusions br Funding br

  2024-10-12

  

  Conclusions Funding Acknowledgements and Disclosures We would like to thank veterinarian Angelina Williams and assistants Justin Courson, Ashutosh Jnawali, Mythri Puella, Santoshi Ramachandran, and Zhihui She for support during dissections. We also thank Drs. Vallabh Das, Deborah Otteson an

• WAY 316606 A review has recently been

  2024-10-12

  

  A review has recently been published to evaluate the potential effects of food, alcohol and WAY 316606 juices on the pharmacokinetics and pharmacodynamics of the drugs for BPH. The authors reviewed the PubMed database during the years 1991–2015. In addition, a digital version of Stockley on drug in

• br Author contributions br Conflict of interest br Acknowled

  2024-10-12

  

  Author contributions Conflict of interest Acknowledgements This work was supported by the National Natural Science Foundation of China (81502276), Major Projects of Science and Technology of Health and Family Planning Commission of Hunan Province (A2017013), the Natural Science Foundation o

• br Research perspective In vitro and in vivo studies have

  2024-10-12

  

  Research perspective In vitro and in vivo studies have demonstrated that increased LPA/ATX signaling contributes to cancer initiation and progression. Recent findings on the role of non-tumoral ATX in cancer progression and metastasis highlighted a new functional contribution for the microenviron

• br Role of autophagy in alcoholic cardiomyopathy br Concludi

  2024-10-12

  

  Role of autophagy in alcoholic cardiomyopathy Concluding remarks The genetic and phenotypic heterogeneity in alcoholic cardiac injury has been recognized despite the seemingly beneficial effects of low to moderate alcohol consumption [8]. Although oxidative stress is well established in the pa

• br Experimental br Results and discussion br Conclusion br

  2024-10-12

  

  Experimental Results and discussion Conclusion Acknowledgments This work is supported by the National Basic Research Program of China (973 Program 2016YFA0201201 and 2013CB932702), a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAP

• Compound was synthesized by reacting amino methoxybenzoate

  2024-10-12

  

  Compound 31 was synthesized by reacting 5-amino-2-methoxybenzoate (28) with ethanesulfonyl chloride in the presence of pyridine in DCM to give sulfonamide 29. Hydrolysis of 29 by aqueous sodium hydroxide afforded the Tenovin-1 30 which was converted to the acid chloride by heating in thionyl chlori

• To the best of our

  2024-10-12

  

  To the best of our knowledge, only 3 cases of an E196K mutation have been described since it was first identified in 2000 [15], [16], [17], although 5 cases, accounting for 1.1% of all genetic TSE cases, were reported with no precise data on the clinical phenotypes in the EUROCJD collaborative surve

• An ALK rearrangement was found

  2024-10-11

  

  An ALK rearrangement was found in all the analyzable ‘truly positive’ IHC+/FISH+ samples, and the proportion of the various transcripts was in accordance with the literature [[26], [46], [47], [48]]. In these samples, the RNA-seq technique was therefore 100% sensitive and specific. Additional non-ta

15041 records 22/1003 page Previous Next First page 上5页 2122232425 下5页 Last page