• NLX a k a F or befiradol exhibits nanomolar

  2023-01-26

  

  NLX-112 (a.k.a. F13640 or befiradol), exhibits nanomolar affinity at 5-HT1A receptors, and, in Neuropeptide Y 13-36 (porcine) australia to the 5-HT1A receptor agonists listed above, it presents exceptional selectivity and high efficacy at these receptors (Colpaert et al., 2002, Newman-Tancredi et al

• CI 976 br Autophagy and cell death pathways

  2023-01-26

  

  Autophagy and cell death pathways in ischemic stroke Although very important for the effects on post-ischemic CI 976 injury, autophagy is not the only mechanism of action involved in cell death. Necrosis and apoptosis are two other distinct forms of cell death with great difference in morphology

• Our results clearly demonstrate that inhibition of ATM pathw

  2023-01-26

  

  Our results clearly demonstrate that inhibition of ATM pathway activation results in resistance to Vγ2Vδ2 T cell-mediated cell death. Therefore, enhancing ATM activation along with Vγ2Vδ2 T cell treatment would promote the cytotoxicity of resistant ovarian cancer cells. To our knowledge, this is the

• br STAR Methods br Author Contributions

  2023-01-24

  

  STAR★Methods Author Contributions Acknowledgments This study is funded by National Institutes of Health (NIH) Grants NS028901 and DC004450 (to L.O.T.); N.L. Tartar Trust Fellowship (to H.-W.L.); DC014878 to T.S.B. We thank members of the Trussell lab for helpful discussions, Dr. Stephen Dav

• It was recently shown that AHR

  2023-01-24

  

  It was recently shown that AHR and HIF-1α cooperate to support the metabolism of Tr1 prolyl hydroxylase [6]. Interestingly, AHR and HIF-1α act sequentially to orchestrate the metabolic remodeling of lymphocytes. While HIF-1α regulates the early metabolic reprogramming of Tr1 cells, AHR takes over a

• It is well known that TCDD

  2023-01-24

  

  It is well-known that TCDD is the most potent ligand of AhR and it regulates gene expression, such as CYP1A1, via activation of AhR (Mimura and Fujii-Kuriyama, 2003). Besides Tomblin et al. (2016) have recently shown that TCDD via AhR regulated L-type amino cam kinase ii transporter 1 expression in

• br Experimental procedure br Introduction Migraine is a

  2023-01-24

  

  Experimental procedure Introduction Migraine is a debilitating neurovascular disorder characterized by recurring unilateral pulsating headaches of moderate to severe intensity, associated with nausea, photophobia and/or phonophobia, lasting from 4 to 72 h (Headache Classification Committee of

• Streptomycetes are a group of filamentous Gram positive

  2023-01-24

  

  Streptomycetes are a group of filamentous Gram-positive, soil-inhabiting bacteria which have captured enormous screening interest because of their ability to produce and secrete a variety of cpi-613 and extracellular proteins [7]. Among the diverse antibiotics produced by Streptomycetes are the nuc

• All consecutive patients who were

  2023-01-24

  

  All consecutive patients who were confirmatively diagnosed with MP-PPE and TPE, respectively, between January 2008 and December 2016 at Kyungpook National University Hospital, a tertiary referral hospital in South Korea, an area with an intermediate prevalence of active tuberculosis, were enrolled.

• br Actin at presynapses br

  2023-01-24

  

  Actin at presynapses Conclusion Thanks to the recent discovery of rings, hotspots and trails, axonal Sulfo-NHS-Biotin is back in the spotlight. These are exiting times for neuronal cell biologists armed with constantly improving labeling and imaging techniques to observe, quantify and perturb

• Cy3 maleimide (non-sulfonated) br Conclusions and future dir

  2023-01-24

  

  Conclusions and future directions Translation of the therapy to human MG will require a substitute adjuvant for IFA. Most human vaccines use aluminum salts (alum) as adjuvants. Both IFA and alum selectively promote antibody dominated Th 2 immune responses, rather than T killer cell dominated Th 1

• TUNEL assay Apoptotic DNA fragmentation

  2023-01-24

  

  TUNEL assay. Apoptotic DNA fragmentation in glatiramer acetate was measured using a commercially available TUNEL assay kit (Thermo Fisher). Frozen cells were fixed with 10% paraformaldehyde/PBS. Apoptosis was determined by staining the 3′-OH ends of fragmented DNA with biotin-dNTP using DNA I klenow

• Furthermore because most of foods and beverages

  2023-01-24

  

  Furthermore, because most of foods and beverages have been consumed after processing, researchers have focused on the effects of processing (e.g. blanching, cooking, drying, cooling, freezing, high-pressure treatment, pulsed electric field) on total antioxidant capacity of foods. In general, there w

• HMGA proteins have also been linked to localized changes in

  2023-01-24

  

  HMGA proteins have also been linked to localized changes in chromatin/nucleosome structure and alterations of cellular phenotype during induction of gene transcription in activated T lymphocytes. An adaptive immune response is initiated when naïve resting T lymphocytes encounter their corresponding

• A characteristic of iron present

  2023-01-21

  

  A characteristic of iron present in brain fluids is considerable differences between measured values of ferritin and transferrin and the total iron content value (Table 1). Variation of the latter is compatible with differences in individual metabolisms. However differences between total iron conten

15800 records 320/1054 page Previous Next First page 上5页 316317318319320 下5页 Last page