• The in vitro studies support our previous observations of a

  2020-07-30

  

  The in vitro studies support our previous observations of a bimodal expression pattern of B. malayi transcripts after tetracycline treatment, including the two enzymes we studied here. We hypothesize that this bimodal expression may be due to stage-specific responses of the host in response to Wolba

• There is now compelling evidence that reactive oxygen

  2020-07-30

  

  There is now compelling evidence that reactive oxygen species induced by sleep fragmentation and intermittent hypoxia might be involved in the activation of systemic inflammation in SDB [29], [30], completely different from the mechanism underlying the upper-airway inflammatory responses. A question

• However it is not clear whether

  2020-07-30

  

  However, it is not clear whether CysLTs induce eosinophilic migration in vitro. Nagy et al. reported that neither leukotriene C4 (LTC4) nor leukotriene D4 (LTD4) caused chemotaxis of eosinophils [5]. However, Spada et al. reported contradictory findings, showing that CysLTs elicit chemotactic activi

• Magnified regions of the upregulated proteins identified by

  2020-07-30

  

  Magnified regions of the upregulated proteins identified by MALDI-TOF are shown in Fig. 2. The identified proteins were phosphoglycerate kinase, fructose-bisphosphate aldolase class II, alcohol dehydrogenase, phosphoglyceromutase, 6-phosphogluconolactonase, malate dehydrogenase, alkyl hydroperoxide

• br Funding sources br Introduction Psychiatric comorbidities

  2020-07-30

  

  Funding sources Introduction Psychiatric comorbidities affect up to 70% of people with pharmacoresistant epilepsy and significantly impact quality of life [1]. Psychiatric comorbidities in epilepsy have been thought to be due to psychosocial stress. However, recent evidence suggests a more com

• br Background of chloride channels Anion selective

  2020-07-30

  

  Background of chloride channels Anion selective AICAR phosphate have been classified into several group based on functional properties such as voltage dependence, single conductance, selectivity, sensitivity to blockers, kinetics, molecular structures and subcellular localization. Electrophysiolo

• We had previously observed a decrease in unspliced

  2020-07-29

  

  We had previously observed a decrease in unspliced, intron-containing HIV mRNA in infected murine cells (Coskun et al., 2007, Coskun et al., 2006, Elinav et al., 2012). The presence of human chromosome 2 in murine cells largely reversed this defect and significantly enhanced infectious virus product

• br Results br Discussion In this

  2020-07-28

  

  Results Discussion In this report, we have presented strong evidence that E1-L2 forms a thioester with FAT10 both in vitro and in vivo. After our manuscript was submitted, Jin et al. and Pelzer et al. reported that E1-L2/Uba6 could activate ubiquitin, but not FAT10 (Jin et al., 2007, Pelzer et

• dopamine hydrochloride In vivo C and C are non redundant in

  2020-07-28

  

  In vivo, C4 and C16 are non-redundant in that dopamine hydrochloride of either caused reduced virulence after i.n. infection (Ember et al., 2012, Fahy et al., 2008), and a double deletion virus was attenuated further. In contrast, redundancy was observed in the i.d. model because deletion of either

• The reduced DNA stability at RH

  2020-07-28

  

  The reduced DNA stability at 100% RH confirms previous results for incubates at these conditions, although in the present study amplifiable DNA still survived for months. The crucial point appears to be the onset of microbial growth, which happened at room temperature and at 35 °C. In the biological

• We found that both DDR

  2020-07-28

  

  We found that both DDR1 and DDR2 ECD increased matrix mineralization as compared to native cells, with the effect of DDR2 ECD being more prominent. Both soluble (DDR2/ECD) and membrane-bound DDR2 ECD (DDR2/-KD), when compared to wild-type cells, induced larger mineral deposits. In this regard, a rec

• Because chemokines and chemokine receptors play

  2020-07-28

  

  Because chemokines and chemokine receptors play an important role in the immune system [26], they have been extensively studied in mammals. For example, Matsuo [27] reported that the CXC-type chemokine/CXCR2 biological axis promotes angiogenesis in vitro and in vivo in pancreatic cancer. Zou [28] re

• Collagen genes encode long polypeptidic chains called

  2020-07-28

  

  Collagen genes encode long polypeptidic chains called α-chains that contain unique structural signature, the presence in their primary structure of the [Gly-X-Y] amino-acid repeats, where X and Y are often a proline and a hydroxyproline respectively. This results in the formation of a triple helix,

• The hypocholesterolemic effect of curcumin was previously co

  2020-07-28

  

  The hypocholesterolemic effect of curcumin was previously considered to be related to the regulation of hepatic LDL receptor, HMG-CoA reductase, and cholesterol 7α-hydroxylase (CYP7A1) [19], [28], [29], [30]. Several studies have indicated that curcumin upregulated LDL receptor expression and increa

• Finally by injecting zymosan A into the hindpaw the contribu

  2020-07-27

  

  Finally, by injecting zymosan A into the hindpaw the contribution of EP1 to pain sensitization was studied in a model that resembles a more complex natural inflammation (). This was particularly important as the expression of EP receptors might change during inflammation. In wild-type mice, zymosan

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