• Another important advantage of this technical report is the

  2018-11-06

  

  Another important advantage of this technical report is the successful application of dCas9 activators for validation of PAX7 knock-in reporter PR171 (Cheng et al., 2013). By design and assembly of site-specific dCas9 activators for PAX7 in human iPS cells, these activators have been screened for i

• We recently reported that iPSCs can

  2018-11-06

  

  We recently reported that iPSCs can be generated using non-modified mRNA (Arnold et al., 2012). In this report we will focus on the crucial steps for successfully applying this method. Material and methods Results Discussion Acknowledgments The work was supported by funding from the Ger

• br Materials and method br Results br

  2018-11-06

  

  Materials and method Results Discussion Here we took advantage of a well-characterized model of skeletal muscle damage to study the effect of FAP ablation on skeletal muscle regeneration in vivo. Our results show that Nilotinib can effectively prevent transient ECM deposition following acut

• Gene expression analysis revealed that cells differentiated

  2018-11-06

  

  Gene expression analysis revealed that cells differentiated for up to 30 days expressed markers implicated in endoderm specification and TEC development but lacked the expression of important late-stage TEC markers associated with functional maturation. In particular, relative to human pediatric thy

• An important question that remains an area of ongoing work

  2018-11-06

  

  An important question that remains an area of ongoing work is to determine whether the sustained presence of Tregs after hNPC rejection continues to dampen neuroinflammation long term. We believe this is possible because hNPCs had already disappeared from the spinal cord at the time we detected incr

• Although the present study focuses predominantly

  2018-11-06

  

  Although the present study focuses predominantly on keratinocytes, it has been known for many years that fibroblasts play an important role in wound healing and in remodeling the extracellular matrix. Thus, an ideal bioengineered graft will always need to incorporate fibroblasts as well as keratinoc

• Our results suggest that specific HDACs play distinct roles

  2018-11-06

  

  Our results suggest that specific HDACs play distinct roles in the differentiation of NSCs. Chemical or genetic ablation of class I HDAC activity have been reported to inhibit oligodendrocyte and Schwann cell differentiation and promote neuronal differentiation (Copray et al., 2009; Hsieh et al., 20

• br Particle motion near the plane of

  2018-11-05

  

  Particle motion near the plane of symmetry is usually studied in so-called paraxial approximation, taking into account terms in till only. It is interesting to carry out a numerical experiment for estimating a real number of terms needed. Analytical calculations may be rather cumbersome, but the

• Which kinase could be responsible for S phosphorylation

  2018-11-05

  

  Which kinase could be responsible for S65 phosphorylation? Mouse NANOG has so far only been found to be phosphorylated by ERK1 in differentiating mESCs at serine residues other than S65, resulting in reduced NANOG protein stability (Kim et al., 2014). Such reported destabilizing effects of ERK1-medi

• For example if f h

  2018-11-05

  

  For example, if f(h)=h, then (this is a rough estimate). We should note here that Varin announced an unprecedented exact value of α=0.33205… (by 32 digits!), with an unlimited accuracy [1,3] (see also a brief summary in Ref. [4]). Aside from the above-described, the Pade approximation [5] is appli

• The results we obtained are also in a

  2018-11-05

  

  The results we obtained are also in a good agreement with the photoconductivity spectra under excitation by p- or s-polarized light in a structure similar to the one we examined, also containing wide doped QWs [10], where a broad ML365 line associated with the 1→e1 and 1→2 transitions was also obse

• UC 112 Few have compared resilience of

  2018-11-05

  

  Few have compared resilience of older men and women. In contrast to our findings and using a different measure of resilience among a British population women showed greater resilience than did men (Netuveli, Wiggins, Montgomery; Hildon, & Blane, 2008). Conclusion Acknowledgements This researc

• br Funding and conflict of interest

  2018-11-05

  

  Funding and conflict of interest statements Acknowledgements We would like to acknowledge funding received from the Canadian Institutes of Health Research (award number GSD-134926) and the Lawson Foundation, Canada (grant number GRT 2011-013). We would also like to thank Dr. Mieke Koehoorn for

• We address this problem from a computational modeling point

  2018-11-05

  

  We address this problem from a computational modeling point of view, and build an ABM that simulates the outcomes of different targeting methods including selected realistic factors that may interact. There exists a limited but rapidly developing literature for modeling social influence on obesity p

• To support claims of benefit in terms of

  2018-11-05

  

  To support claims of benefit, in terms of reduced environmental burden or increased process sustainability, rigorous process analysis is required using tools such as Life Cycle Assessment or carbon- and water footprinting. These approaches require availability of material and MM-102 inventories, as

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