• Recent approaches toward more efficacious interventions agai

  2018-10-23

  

  Recent approaches toward more efficacious interventions against TB, including shortening the length of the chemotherapy, include host-directed therapy (HDT) (). HDTs that focus on modulation of click here comprise strategies to release immune suppression and enhance anti-microbial mechanisms, or al

• The PMDA address two conflicting goals the first is to

  2018-10-23

  

  The PMDA address two conflicting goals: the first is to assure the public that the devices are reasonably safe and effective; and the second is to avoid overregulation of manufacturers in the development of Class III or IV devices (Post-marketing measures for drug/medical devices). The PMDA shifted

• br Discussion Standard protocols of the assessment of neurop

  2018-10-23

  

  Discussion Standard protocols of the assessment of neuropathic pain have been widely agreed for specialist settings and primary care (Haanpää et al., 2011; Jones & Backonja, 2013). However, there is no common approach or consensus reached by clinicians or researchers to define neuropathic pain in

• Although our results suggest an association between NFKBIE

  2018-10-23

  

  Although our results suggest an association between NFKBIE, and possibly NFKBIA, and susceptibility to IPD, we cannot exclude that the SNPs are in LD with disease-associated polymorphisms in nearby causative protease inhibitor (Gabriel et al., 2002). This makes replication in independent population

• To calculate the intensity and duration of dengue transmissi

  2018-10-23

  

  To calculate the intensity and duration of dengue transmission, a seasonality curve was generated by plotting the decadally averaged VC as a function of month for each of the 10 cities first and then for each decade over the two centuries. The intensity of DEP was estimated by averaging the VC over

• Non supervised clustering of gene

  2018-10-23

  

  Non-supervised clustering of gene expression divided the ALLs into eight subgroups. It will be interesting to learn if these subgroups overlap with the ones reported by Harvey et al. for an American cohort for pediatric ALLs (). The most significant findings are the discoveries of in-frame fusions o

• Stratifying patients according to the toxicity risk and

  2018-10-23

  

  Stratifying patients according to the toxicity risk and modulating EBRT dose would provide a valuable tool for personalized EBRT (). Many efforts have been made to develop assays capable of predicting susceptibility for the development of radiation injury that finally allow customization of EBRT pro

• We also noticed that there are statistically significant

  2018-10-23

  

  We also noticed that there are statistically significant differences in protein abundance levels depending on the season, or month, the samples were collected. After adjusting our protein abundance levels for storage time and individual age, we found only nominally significant associations with mont

• Sample collection for a cohort is often carried out

  2018-10-23

  

  Sample collection for a cohort is often carried out at the time of diagnosis, time of treatment or time of screening of healthy individuals, and not confined to a certain time of the year. This implies that environmental factors, such as pollen concentration in the spring, may cause downstream effec

• Machine learning is a branch

  2018-10-23

  

  Machine learning is a branch of AI-based methods that we have applied to examine pathophysiological and clinical parameters as well as therapeutic outcomes in the past, whereby it outperformed standard statistical inference with datasets of as little as 28 patients (Chigutsa et al., 2015; Gumbo et a

• sulfanilamide The extracellular matrix ECM is important for

  2018-10-23

  

  The extracellular matrix (ECM) is important for the integrity of the aortic wall and mutations in ECM genes such as Fibulin-4 and Fibrillin-1 hence lead to aneurysm formation. Genetic studies in Fibulin-4 and Fibrillin-1 mutant mice implicated dysregulation of the TGF-β pathway as an important hallm

• In accordance with the results of other

  2018-10-23

  

  In accordance with the results of other previous clinical studies, in this study the presence of maternal antibody was also suggested in infants monoclonal lenvatinib also correlated with serum neutralization titers. The kinetics of PLNA in samples of children aged at 25 to 36months old and adults

• As opposed to schwannomas other driver mutations

  2018-10-23

  

  As opposed to schwannomas, other driver mutations have been identified in meningioma, but those are mutually exclusive of Merlin (Clark et al., 2013). In order to keep the genetic background consistent with schwannoma, we analysed only Merlin-deficient WHO grade I meningiomas. Comparative functional

• So far RIO kinases have been

  2018-10-23

  

  So far, RIO kinases have been mostly studied in yeast, but the few studies addressing their function in mammalian cells identified an important role of all three family members in ribosomal biogenesis (Baumas et al., 2012; Ferreira-Cerca et al., 2014; Ferreira-Cerca et al., 2012; Turowski et al., 20

• The CS SVM classifier can select a small subset

  2018-10-23

  

  The CS-SVM classifier can select a small subset of stage II and III patients who can specifically benefit from 5-FU/oxaliplatin chemotherapy. Patients identified as high CS-SVM benefited significantly from chemotherapy in the training cohort (DFS, 0.001; OS, 0.0003; Fig. 5). In contrast, low CS-SVM

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