• Gene expression is regulated by complex coordinated

  2018-11-06

  

  Gene expression is regulated by complex coordinated processes, including chromatin remodeling, post-translational modifications of histones, and incorporation of non-allelic histone variants. The histone variant H2AZ constitutes only a few percents of the total H2A cellular pool (). However, H2AZ is

• In this study we report the creation of the first

  2018-11-06

  

  In this study, we report the creation of the first genetically modified large animal model of a metabolic liver disorder, HT1, in pigs that are deficient in FAH, an enzyme that catalyzes the last step in tyrosine metabolism (Lindblad et al., 1977). Based on the results presented here, we believe FAH

• The identification of new stem cell markers characteristic o

  2018-11-06

  

  The identification of new stem cell markers characteristic of a phenotypic subset or experimental state remains a major ap1 research goal. Researchers may wish to assess the uniqueness of an expression profile before embarking on experiments that rely on a reporter gene or antibody to select for a

• Defining regeneration as the replacement of

  2018-11-06

  

  Defining regeneration as “the replacement of missing structures following injury” (Morgan, 1901), compensatory lung growth after pneumonectomy is an extraordinary example of mammalian tissue regeneration. After left pneumonectomy, the missing lung tissue is not regrown orthotopically in the left hil

• Placental growth factor PlGF is an angiogenic

  2018-11-06

  

  Placental growth factor (PlGF) is an angiogenic protein often highly upregulated in solid tumors contributing to their growth and survival (Kim et al., 2012). PlGF can promote angiogenesis either by directly stimulating endothelial cell growth or by recruiting pro-angiogenic cell types. Of the two m

• Ramelteon It is well established that a host of factors with

  2018-11-06

  

  It is well established that a host of factors within the injured microenvironment are capable of activating circulating Ramelteon and platelets and thus permitting their endothelial adhesion during inflammatory processes (Mori et al., 2005a; Vowinkel et al., 2007; Sprague and Khalil, 2009; Santen e

• Another important advantage of this technical report is the

  2018-11-06

  

  Another important advantage of this technical report is the successful application of dCas9 activators for validation of PAX7 knock-in reporter PR171 (Cheng et al., 2013). By design and assembly of site-specific dCas9 activators for PAX7 in human iPS cells, these activators have been screened for i

• We recently reported that iPSCs can

  2018-11-06

  

  We recently reported that iPSCs can be generated using non-modified mRNA (Arnold et al., 2012). In this report we will focus on the crucial steps for successfully applying this method. Material and methods Results Discussion Acknowledgments The work was supported by funding from the Ger

• br Materials and method br Results br

  2018-11-06

  

  Materials and method Results Discussion Here we took advantage of a well-characterized model of skeletal muscle damage to study the effect of FAP ablation on skeletal muscle regeneration in vivo. Our results show that Nilotinib can effectively prevent transient ECM deposition following acut

• Gene expression analysis revealed that cells differentiated

  2018-11-06

  

  Gene expression analysis revealed that cells differentiated for up to 30 days expressed markers implicated in endoderm specification and TEC development but lacked the expression of important late-stage TEC markers associated with functional maturation. In particular, relative to human pediatric thy

• An important question that remains an area of ongoing work

  2018-11-06

  

  An important question that remains an area of ongoing work is to determine whether the sustained presence of Tregs after hNPC rejection continues to dampen neuroinflammation long term. We believe this is possible because hNPCs had already disappeared from the spinal cord at the time we detected incr

• Although the present study focuses predominantly

  2018-11-06

  

  Although the present study focuses predominantly on keratinocytes, it has been known for many years that fibroblasts play an important role in wound healing and in remodeling the extracellular matrix. Thus, an ideal bioengineered graft will always need to incorporate fibroblasts as well as keratinoc

• Our results suggest that specific HDACs play distinct roles

  2018-11-06

  

  Our results suggest that specific HDACs play distinct roles in the differentiation of NSCs. Chemical or genetic ablation of class I HDAC activity have been reported to inhibit oligodendrocyte and Schwann cell differentiation and promote neuronal differentiation (Copray et al., 2009; Hsieh et al., 20

• br Particle motion near the plane of

  2018-11-05

  

  Particle motion near the plane of symmetry is usually studied in so-called paraxial approximation, taking into account terms in till only. It is interesting to carry out a numerical experiment for estimating a real number of terms needed. Analytical calculations may be rather cumbersome, but the

• Which kinase could be responsible for S phosphorylation

  2018-11-05

  

  Which kinase could be responsible for S65 phosphorylation? Mouse NANOG has so far only been found to be phosphorylated by ERK1 in differentiating mESCs at serine residues other than S65, resulting in reduced NANOG protein stability (Kim et al., 2014). Such reported destabilizing effects of ERK1-medi

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