• H O can degrade haemoglobin to release Fe ions

  2018-10-22

  

  H2O2 can degrade haemoglobin, to release Fe2+ ions that can lead to erythrolysis. Azizova et al. [39] showed that erythrocyte membranes during atherosclerotic conditions are prone to lysis in the presence of oxidized LDL. We found that EOC could efficiently inhibit lipid peroxidation, which supports

• To study this complex neuroprotective

  2018-10-22

  

  To study this complex neuroprotective pathway, a common endpoint needs to be identified. A potential pathway involves the regulation of the major cellular antioxidant glutathione. Glutathione biosynthesis, which begins with the import of cystine dimers through the cystine glutamate exchanger (System

• In summary we have dissected the specific

  2018-10-22

  

  In summary, we have dissected the specific role that OCT4 plays during the first steps of reprogramming independently of the other reprogramming factors. We have shown that OCT4 does not require SOX2 to interfere with cell-type-specific gene-expression profiles or to initiate an unstable transcripti

• Previously the donor to donor heterogeneity in MSCs has been

  2018-10-22

  

  Previously, the donor-to-donor heterogeneity in MSCs has been revealed through significant differences in growth rate and clonogenic potential (Phinney et al., 1999). Such inter-subject variabilities (donor-to-donor) have been considered to be caused for the most part by factors imposed by long-term

• br Introduction Hypoxic ischemic HI injury to

  2018-10-22

  

  Introduction Hypoxic–ischemic (HI) injury to the prenatal and perinatal glucocorticoid receptor is a major contributor to global child mortality and morbidity (Volpe, 2001). Perinatal hypoxic–ischemic injury affects between 1 and 8 per 1000 full-term infants and nearly 60% of low birth-weight (p

• One approach to generate specific cell populations is to dir

  2018-10-22

  

  One approach to generate specific cell populations is to direct PSCs toward a desired cell type by sequential progression through intermediate cell populations, mimicking the stages of embryonic development. Monolayer differentiation approaches allow homogeneous accessibility of PF-3758309 cost to

• Whereas continuous exposure to all three

  2018-10-22

  

  Whereas continuous exposure to all three factors (4+) resulted in higher levels of DE genes, there was no significant difference in the proportion of Foxa2+Sox17+ cysteine protease when compared to transient Wnt activation (2+2−). Surprisingly, T expression in a fraction of differentiated cells was

• Inefficient DNA DSB repair can promote genomic rearrangement

  2018-10-20

  

  Inefficient DNA DSB repair can promote genomic rearrangements which can lead to malignant transformations (Reya et al., 2001) thus leading to the notion that stem cells with compromised genome integrity commit altruistic suicide or differentiate, and are more sensitive to DNA damage than other cells

• Interestingly the migration kinetics of

  2018-10-20

  

  Interestingly, the migration kinetics of type B astrocytes was similar to that previously described for neuroblasts (Elvira et al., 2012). This suggests that both cell types are able to respond to the same “damage signals” and that type B astrocytes could help in neuroblast migration as previously s

• Host pathogen interaction is a balancing

  2018-10-20

  

  Host-pathogen interaction is a balancing act as viruses evolved to have strategies to evade the host defense system. HCV NS3, core and NS5A proteins are involved in immune evasion by modulating specific and innate immune pathways (Basu et al., 2001; Horner and Gale, 2013). NS3 protease can effective

• The negative regulation of Zac expression by SOXB

  2018-10-20

  

  The negative regulation of Zac1 expression by SOXB1 transcription factors combined with the decrease of Sox2 expression as the levels of Zac1 increase suggest that ZAC1 and SOXB1 factors could act as a cross-repressive genetic switch governing the acquisition of distinct cellular identities (Enver e

• The first line of treatment for the majority of primary

  2018-10-20

  

  The first-line of treatment for the majority of primary malignant molecular weight calculator tumors is maximal safe resection followed by radiation therapy, with or without chemotherapy, based on numerous studies that demonstrate a survival benefit with the addition of radiation (Stupp et al., 200

• br Resource table br Resource details Spastic paraplegia

  2018-10-20

  

  Resource table Resource details Spastic paraplegia gene type 5 (SPG5) is an autosomal recessive subtype of hereditary spastic paraplegia caused by mutations in CYP7B1, a gene encoding for the cytochrome P-450 oxysterol 7-α-hydroxylase, essential for the liver-specific alternative pathway in bi

• To derive hiPSC from patient fibroblasts we adopted

  2018-10-20

  

  To derive hiPSC from patient fibroblasts, we adopted previous protocols (Okita et al., 2011; Rasmussen et al., 2014) and electroporated the patient\'s skin fibroblasts with episomal plasmids expressing human OCT4, SOX2, L-MYC, KLF4, NANOG, LIN28, and short hairpin RNA against TP53. To demonstrate th

• br Materials and methods br Author disclosure statement br A

  2018-10-20

  

  Materials and methods Author disclosure statement Acknowledgments This study was supported by fund from National Medical Research Council (NMRC) of China to SZ (fund number: 30400447) and HW (fund number: 30500548). Resource table. Resource details To engineer a biallelic mutation in

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