• br Antioxidative stress and anti inflammation Oxidative

  2024-12-26

  

  Antioxidative stress and anti-inflammation Oxidative stress is a major cause of reduced endothelial NO bioavailability in hypertension, and inflammatory response is thought to play an important role in these processes (Blake and Ridker, 2001, Landmesser et al., 2006). Reactive oxygen species (ROS

• All scientific data over the years points

  2024-12-26

  

  All scientific data over the years points that 5α-reductase inhibitors undoubtedly are an effective treatment for BPH and associated LUTS, having a favorable risk-benefit profile. In contrast, although some studies indicated positive results, there is still no consensus about their use in BPH or PC

• Our sample is representative of mRCC treated

  2024-12-26

  

  Our sample is representative of mRCC treated with sunitinib. However, the results from CCC setting have limited inference due to small exploratory sample (n = 51). Additionally, the significance of survival differences in CCC according to AXL staining is tangential. Unfortunately, we were unable to

• br Synthetic lethal approaches In addition to

  2024-12-26

  

  Synthetic lethal approaches In addition to the potential utility of ATM and ATR as chemo- or radiosensitisers, recent studies suggest that such compounds may have single agent activity in certain subsets of patients through induction of synthetic lethality. Two genes are considered synthetically

• TLRs play a key role in pathogen recognition

  2024-12-26

  

  TLRs play a key role in pathogen recognition and early response. In our study, we showed an increase of TLR2 mRNA and protein expression after BMECs were stimulated by S. aureus, as seen for BMECs in a previous study [25]. Although most studies describe TLR4 as a primary receptor for Gram-negative b

• br Experimental section br Acknowledgements

  2024-12-26

  

  Experimental section Acknowledgements This work was funded by the Italian Association for Cancer Research (AIRC IG18590 to A.A.), by “Fondi di Ateneo-University of Pisa” years 2009 and 2010 (E. N., S. N., E. O., and A. R.) and partially by the Unipi project P.R.A.2016_27 (E. N., E.O. and A. R.

• The apocrine sweat glands of

  2024-12-26

  

  The apocrine sweat glands of the human axilla produce odor substances with pheromone functions whose nature corresponds to volatile steroids (Cowley and Brooksbank, 1991, Grosser et al., 2000, Sobel et al., 1999, Weller, 1998). These functions only begin with puberty, indicating that sex hormones st

• Spectroscopic techniques are powerful biophysical tools used

  2024-12-25

  

  Spectroscopic techniques are powerful biophysical tools used in the study of biomolecular structures, including those of proteins. UV–Vis 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodouracil spectroscopy makes use of absorption property of the protein peptide backbone at around 218 nm, and aromat

• Previous studies to investigate the functions of AHR in

  2024-12-25

  

  Previous studies to investigate the functions of AHR in Treg Enhancer of zeste homolog 2 inhibitor have employed a loss-of-function approach, using AHR complete-null mice, or a gain-of-function approach by ligand administration. However, these approaches may confound the interpretation of the resul

• dNTPs for DNA synthesis Adenosine is an endogenous nucleosid

  2024-12-25

  

  Adenosine is an endogenous nucleoside that plays pivotal roles in different physiological and pathophysiological processes by triggering specific cell-surface receptors both in the dNTPs for DNA synthesis and in the periphery. The adenosine receptors (ARs) are four different subtypes of G protein-co

• Several studies have recently used optogenetics to

  2024-12-25

  

  Several studies have recently used optogenetics to selectively activate various cholinergic neurons (Jiang et al., 2014). However, most do not explicitly report direct release of GABA from cholinergic fibers, with the exception of our two studies described above (Saunders et al., 2015a, Saunders et 

• The first rationally designed dual

  2024-12-25

  

  The first rationally designed dual mPGES-1/5-LO inhibitor was reported in 2008 and represents a structural derivative of pirinixic GSA 10 - a synthetic agonist of PPARα with lipid-lowering properties (Koeberle et al., 2008b). Further α-alkyl- and α-aryl-substituted derivatives have been synthesized

• These results show that quercetin can restore the

  2024-12-25

  

  These results show that quercetin can restore the enzyme activity of the cholinergic system nonneural induced by demyelination. The AChE activity has been used as an indicator of human cell aging with lowered levels commonly associated with older human red blood Vincristine sulfate [51]. The enzyme

• The ambiguity surrounding the role played by the LOXs

  2024-12-24

  

  The ambiguity surrounding the role played by the 15-LOXs in malignant biological processes stems also from the limitations of current animal models, and especially the usage of its 12/15-LOX murine homolog, which can also catalyze the production of 12-HETE. Indeed, the proinflammatory effect of 12-H

• deity tc-1 In pancreatic islets we found an increase in

  2024-12-24

  

  In pancreatic islets we found an increase in protein expression of leukocyte 12/15-LO that paralleled the metabolic decline characterized by severe hyperglycemia and reduced islet numbers. Similar increase in 12/15-LO expression by Western blot was found in the control mice, which have a normal meta

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