• br Declarations of interest br Acknowledgements This work wa

  2021-10-14

  

  Declarations of interest Acknowledgements This work was supported by the National Natural Science Foundation of China (81673321, 21506099), the State Key Laboratory of Drug Research (SIMM1705KF-13), the Natural Science Foundation of Jiangsu Province (Grant No. BK20151541), and the Jiangsu Syne

• In various models histamine has

  2021-10-13

  

  In various models, histamine has been shown to induce chemotaxis. This was first appreciated over 40 years’ ago in studies with eosinophils (Clark et al., 1977). At that time, only histamine H1 and histamine H2 receptors were recognized and studies with ligands to these receptors indicated that neit

• CD CD belong to the costimulatory adhesion molecule family

  2021-10-13

  

  CD80/CD86 belong to the costimulatory adhesion molecule family, which can activate T Fesoterodine Fumarate by the costimulatory pathway and have been used as indicators of DC maturation in numerous studies. In addition, MHC-II, as the principal component of antigen presentation, was significantly e

• Now recall that a cozero element

  2021-10-13

  

  Now recall that a cozero estrogen receptor antagonist of a frame L is an element of the form for some continuous real-valued function h in L. Equivalently, is a cozero element if and only if there exists an such that and . This is the pointfree counterpart to the notion of a cozero set for ordin

• The Y H D A variant was resistant to all

  2021-10-13

  

  The Y56H/D168A variant was resistant to all tested PIs, and the inhibitor binding mode determined the molecular mechanism of resistance. Prior to the development of grazoprevir, PIs typically contained large heterocyclic P2 moieties that strongly interacted with S2-subsite residues (Ali et al., 2013

• Mice with GSTP knock out show

  2021-10-13

  

  Mice with GSTP1 knock out show increased risk of skin cancer when exposed to carcinogens like polycyclic aromatic hydrocarbons [23]. Most of the genetic association studies have focused on GSTP1 c.313G > A variant which results in isoleucine to valine substitution at amino 15 residue number 105 in

• Historically pharmacological investigations have been

  2021-10-13

  

  Historically, pharmacological investigations have been carried out by first identifying a biological response to a ligand, and then subsequently using that ligand to identify the receptor(s) responsible for the response (Wilson et al., 1998). However, this approach needed revision with the discovery

• We also investigated fat depots in mesenteric

  2021-10-13

  

  We also investigated fat depots in mesenteric and retroperitoneal adipose tissues as well as in the liver and verified a reduction in lipid droplets following exercise or exercise and FS oil treatments in the liver from obese mice. Potential molecular candidates in the modulation of adipose tissue b

• ATP as a transmitter can be released from injured cells

  2021-10-13

  

  ATP as a transmitter can be released from injured BMS265246 and sensory nerve endings (Sperlágh et al., 1995, Sperlágh et al., 1997, Sperlágh et al., 1998, Burnstock, 2013, Burnstock, 2014). ATP can activate the P2X3 receptor in the DRG neurons (Gao et al., 2011a; Xu et al., 2012). In DRG neurons c

• In addition to gonadotropes GnRHRs have also been detected o

  2021-10-13

  

  In addition to gonadotropes, GnRHRs have also been detected on somatotropes, lactotropes, thyrotropes, melanotropes, somatolactin (SL) cells, and/or corticotropes using immunohistochemical, radioligand-binding, or mRNA expression approaches across species; including fishes, rats, and humans (La Rosa

• br Genetic rescue of GluR

  2021-10-13

  

  Genetic rescue of GluR-A-dependent spatial working memory Spatial working memory performance in GluR-A−/− mice can be restored by the forebrain-specific AMG-900 of GluR-A subunits labeled with green-fluorescent protein (GFP) on an otherwise GluR-A knockout background (Schmitt et al., 2005). This

• The elective controlled fasting study in our patient provide

  2021-10-13

  

  The elective controlled fasting study in our patient provides further metabolic profiling in patients with GCGR defect. Despite her lean body mass with low weight, at the age of 7 years old she demonstrated a good tolerance for fasting with hypoglycemia fk866 level, insulin, and counter-regulatory

• Methods br Results br Discussion In this report the

  2021-10-13

  

  Methods Results Discussion In this report, the therapeutic effect of a GCGR antagonistic antibody REMD2.59 was tested in 2 mechanistically divergent disease models of heart failure without confounding defects in global metabolism. Based on histological and functional analyses in both MI-injur

• These various observations indicate that GIP

  2021-10-13

  

  These various observations indicate that GIP plays an important role in the normal compensatory islet response to high fat feeding. This likely reflects the loss of the combined actions of intra-islet GIP together with intestinally-derived GIP entering the islet vasculature following secretion from

• br Methods br Results br Discussion TA TMA

  2021-10-12

  

  Methods Results Discussion TA-TMA is a severe complication for patients after HSCT. The pathogenesis of TA-TMA is unclear. Complement activation and endothelial cell injury may be involved in the pathogenesis of TA-TMA. Our previous investigations had demonstrated that plasma levels of C5b-

15752 records 542/1051 page Previous Next First page 上5页 541542543544545 下5页 Last page