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br Heating Up Immunologically Cold Tumours
2018-11-09
Heating Up Immunologically Cold Tumours With an Oncolytic Virus As discussed our immune systems have evolved elaborate mechanisms to react against invading pathogens and rapidly mount immune responses to eliminate the pathogen and in some instances, the cells they infect. OVs are natural pathogen
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The preponderance of laboratory behavioral evidence suggests
2018-11-09
The preponderance of laboratory behavioral evidence suggests that hypersensitivity to rewards may serve as a characteristic or liability factor for DBD (reviewed in Byrd et al., 2014), especially in DBD youth with low levels of anxiety and those exhibiting callous-unemotional (e.g., lack of empathy/
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Introducci n br Caracter sticas
2018-11-09
Introducción Características estructurales del sistema energético nacional El funcionamiento del sistema energético nacional se gestó desde las décadas de 1970 y 1980. En ese marco jurídico e institucional, correspondió al Estado, en exclusividad, el manejo de las actividades centrales de los su
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br Concluding remarks br Acknowledgements I am grateful
2018-11-09
Concluding remarks Acknowledgements I am grateful to two anonymous referees and the editor for their helpful comments. This work was supported by a Grant-in-Aid for Scientific Research (No. 22330090) from the Ministry of Education, Culture, Sport, Science and Technology, Japan. Introduction
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Despite this intriguing connection pre
2018-11-09
Despite this intriguing connection, pre-conditioning with SL-LPS in the context of sepsis mortality has never been studied. Thus, we tested the histamine receptors that SL-LPS pre-conditioning may exacerbate, instead of alleviate sepsis mortality in vivo. We employed the classical cecal ligation an
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The study we report here further
2018-11-09
The study we report here further supports continued development of cysteamine as a novel “re-purposed” candidate CF treatment by confirming activity and therapeutic potential in the biological matrix (CF sputum) and raises the prospect of cysteamine being used to treat M. abscessus. It remains to be
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ATP dependent chromatin remodeling complexes
2018-11-09
ATP dependent chromatin remodeling complexes are another group of factors, which the cell has co-evolved in addition to post-translational histone modifications, in order to alter histone-DNA contacts and change chromatin structure. These multi-subunit protein complexes use energy from ATP hydrolysi
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br Conflicts of Interest br Acknowledgments br Introduction
2018-11-09
Conflicts of Interest Acknowledgments Introduction Eukaryotic cells perform oxidative phosphorylation (OXPHOS), which uses the energy released by the mitochondrial oxidation of certain metabolites, i.e. glucose, to produce adenosine triphosphate (ATP). OXPHOS is an efficient way of releasin
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Infections with eleven species of pathogens
2018-11-09
Infections with eleven species of pathogens associated with cancers are classified as Group 1 carcinogens, definitely “carcinogenic to humans”, by the IARC. These agents include Helicobacter pylori, hepatitis B virus (HBV), hepatitis C virus (HCV), Opisthorchis viverrini, Clonorchis sinensis, Schist
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br Results br Discussion Supplementation of
2018-11-08
Results Discussion Supplementation of the p38 MAPK inhibitor SB203580 has been identified to enhance cardiomyogenesis of human embryonic stem LY335979 at a relative narrow range of 1–10μM whereas higher concentrations >15μM inhibited or blocked cardiac differentiation (Graichen et al., 2008).
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br Intra or extra embryonic origin
2018-11-08
Intra- or extra-embryonic origin of hematopoietic stem cells: A long historical uncertainty It has been impossible so far to ascertain the precise anatomical site(s) of HSC emergence in the mouse conceptus. Indeed, the blood is already circulating (starting at E8.25–8.5) (Ji et al., 2003) between
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AP20187 The generation of hESCs involves
2018-11-08
The generation of hESCs involves numerous reagents, including growth factors, small molecules, and media. To avoid infection by animal-sourced components, mouse feeder AP20187 can be substituted by human fibroblasts (Ellerstrom et al., 2006; Genbacev et al., 2005). Chemically defined hESC culture me
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As PcG proteins and miRNAs
2018-11-08
As PcG proteins and miRNAs are usually co-expressed in many cell types or cancer tissues, such as keratinocytes (Eckert et al., 2011; Yi et al., 2008), hematopoietic stem oxymetazoline hydrochloride (Takamatsu-Ichihara and Kitabayashi, 2016), hepatocellular carcinoma (Yonemitsu et al., 2009), lung
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GABAA receptors GABAAR are heteropentameric ion channels wit
2018-11-08
GABAA receptors (GABAAR) are heteropentameric ion channels with prevalent expression on immature cells, including astrocyte-like SVZ cells, TACs and neuroblasts (Platel et al., 2010). Previous studies reveal that GABAAR activation decreases the proliferation of embryonic neocortical progenitors (Hay
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While the in vivo significance of
2018-11-08
While the in vivo significance of our in vitro findings was examined in xenograft and metastasis studies, we observed a dramatic suppression of tumor growth and metastasis of SW480 CRC cGMP Dependent Kinase Inhibitor Peptide by EDA silencing, which is associated with increased apoptosis and reduce
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